Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia. 15574495

2004
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Truncated APC is required for cell proliferation and DNA replication. 16450383

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. 17128412

2007
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. 11751382

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. 19088039

2008
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate. 15548520

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. 11705852

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. 12839952

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. 12767532

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. 14675489

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. 15896711

2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.560 AlteredExpression LHGDN Low frequency of bcl-2 expression in large non-polypoid colonic neoplasms. 15303767

2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.560 AlteredExpression LHGDN Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway. 15314290

2004
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.540 AlteredExpression LHGDN Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo. 17224907

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.540 AlteredExpression LHGDN Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells. 17186550

2007
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.530 AlteredExpression LHGDN Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. 16543245

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression. 11956638

2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. 15262986

2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN p53 gene mutations are rare in human papillomavirus-associated colon cancer. 14534749

2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. 15386430

2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells. 17634554

2007
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 AlteredExpression LHGDN beta-Catenin signaling in biological control and cancer. 17854061

2007
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 AlteredExpression LHGDN Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. 16543245

2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 AlteredExpression LHGDN Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. 14506281

2003
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.400 AlteredExpression LHGDN Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. 17128412

2007